Document Detail


The development of cystathionase activity during the first year of life.
MedLine Citation:
PMID:  7070878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of hepatic cystathionase (EC 4.4.1.1) activity is dependent both upon the gestational age of the infant and the postnatal age. Full-term infants are born with greater hepatic cystathionase activity than pre-term infants, and the activity increases rapidly after birth reaching mature levels at about 3 months of age. Prematurely born infants have lower hepatic cystathionase activity at birth and like the full-term, the activity increases after birth. Cystathionase activity is not isolated to the liver. In both premature and full-term infants, it is present in the kidneys, and adrenals, but of little significance in the pancreas. These in vitro measurements of cystathionase activity indicate that the premature infant is potentially capable of endogenous cysteine production if provided with adequate methionine.
Authors:
S H Zlotkin; G H Anderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  16     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Cystathionine gamma-Lyase / analysis*
Female
Gestational Age
Humans
Infant
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature
Kidney / enzymology
Liver / enzymology*
Lyases / analysis*
Male
Chemical
Reg. No./Substance:
EC 4.-/Lyases; EC 4.4.1.1/Cystathionine gamma-Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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