Document Detail


The development of basal forebrain projections to the rat visual cortex.
MedLine Citation:
PMID:  2792246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of the basal forebrain projections to the visual cortex of the rat were studied using retrograde tracer techniques. Injections of wheat germ agglutinin-horseradish peroxidase placed in the visual cortex of newborn animals resulted in labelling of neurons throughout the basal forebrain nuclei. Although at this time the overall distribution of retrogradely labelled cells within the basal forebrain appeared similar to that seen in the adult, cells were smaller and weakly stained. It was only at the end of the second postnatal week that the somata of stained neurons showed sizes and staining intensity comparable to the adult. This precedes or coincides with the reported significant increases in cortical and basal forebrain ChAT activity and the first detection of ChAT-labelled fibres in this cortical area. These data suggest an important developmental point around the end of the second postnatal week that may correspond to the time when a significant number of cholinergic axons first appear within the visual cortex. They also suggest that the cholinergic projections to the visual cortex develop late in comparison with the thalamic and other subcortical afferents in this cortical area.
Authors:
A Dinopoulos; L A Eadie; I Dori; J G Parnavelas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental brain research     Volume:  76     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-30     Completed Date:  1989-10-30     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  563-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Animals, Newborn / growth & development,  physiology
Basal Ganglia / enzymology,  growth & development*,  physiology
Choline O-Acetyltransferase / analysis
Cholinergic Fibers / enzymology,  physiology
Immunohistochemistry
Neural Pathways / enzymology,  growth & development
Neurons / enzymology,  physiology*
Rats
Rats, Inbred Strains
Visual Cortex / enzymology,  growth & development*,  physiology
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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