Document Detail


The development of atopic phenotypes: genetic and environmental determinants.
MedLine Citation:
PMID:  17245087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atopic manifestations may be present from infancy to adolescence. Atopic dermatitis represents the first clinical manifestation followed by allergic symptoms of the upper or lower airways. IgE responses to alimentary or environmental allergens are hallmarks of atopy in childhood. Characteristically infantile IgE responses to cow's milk and hen's egg are the first immunological markers of atopy. In many cases they are followed by IgE responses to indoor or outdoor allergens, which suggests a high risk for the development of persistent asthma in childhood. During recent years a variety of genes for both asthma and atopic dermatitis have been described. Infantile diet, early exposure to environmental allergens and a variety of environmental and lifestyle factors may act as strong modulators of atopy during the first decade of life.
Authors:
Ulrich Wahn; Erika von Mutius; Susanne Lau; Renate Nickel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nestlé Nutrition workshop series. Paediatric programme     Volume:  59     ISSN:  1661-6677     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-01-24     Completed Date:  2007-04-02     Revised Date:  2007-09-07    
Medline Journal Info:
Nlm Unique ID:  101244056     Medline TA:  Nestle Nutr Workshop Ser Pediatr Program     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-11; discussion 11-15     Citation Subset:  IM    
Affiliation:
Department of Pneumology, Charité Universitätsmedizin, Augustenburger Platz 1, DE-13353 Berlin, Germany. ulrich.wahn@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asthma / genetics*,  prevention & control
Child
Child, Preschool
Dermatitis, Atopic / genetics*,  prevention & control
Environmental Exposure*
Female
Food Hypersensitivity
Humans
Hypersensitivity, Immediate / genetics*,  prevention & control
Immunoglobulin E / immunology*
Infant
Infant, Newborn
Male
Phenotype
Risk Factors
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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