Document Detail

The development of allergy in high-risk children.
MedLine Citation:
PMID:  9420127     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is uncertain as to what extent the development of allergic disease in childhood is predictable during early infancy. A number of environmental factors have been suspected of increasing the risk of acquiring allergy, but the evidence is conflicting. OBJECTIVE: To observe the development of atopy and allergic disease in a cohort of high-risk children so as to determine the importance of certain environmental factors and to study the relationship between early and later manifestations. METHODS: A cohort of infants, all at high risk of allergy, was followed up from birth to the age of 7 years. In half, selected at random, cow's milk protein was avoided for 4 months. Skin-prick tests were performed and serum IgE measured in infancy and at 7 years, when an AlaTOP test was also performed. RESULTS: Skin sensitivity to egg in the first year of life was strongly associated with eczema, asthma, mite sensitivity and serum IgE at the age of 7 years, when mother's atopic history was associated with AlaTOP status, father's atopic history with skin sensitivity, and male sex with both. Maternal smoking during pregnancy was associated positively with IgE at 3 months and negatively with skin sensitivity at 7 years. The development of allergy was unrelated to infant feeding method or number of older siblings. CONCLUSION: Allergic disease in childhood is to a large degree determined before birth or during infancy.
M L Burr; T G Merrett; F D Dunstan; M J Maguire
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  27     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-25     Completed Date:  1998-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1247-53     Citation Subset:  IM    
Centre for Applied Public Health Medicine, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Age Factors
Child, Preschool
Cohort Studies
Hypersensitivity, Immediate / etiology*,  genetics,  immunology
Immunoglobulin E / immunology
Infant, Newborn
Milk / adverse effects*,  immunology
Sex Factors
Skin Tests
Reg. No./Substance:
37341-29-0/Immunoglobulin E
Comment In:
Clin Exp Allergy. 1997 Nov;27(11):1231-3   [PMID:  9420123 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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