| The development of D2 autoreceptor-mediated modulation of K(+)-evoked dopamine release in the neostriatum. | |
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MedLine Citation:
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PMID: 7911744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A within-subject dose-response analysis was conducted by locally perfusing increasing concentrations (0.1, 1, 10 and 100 microM) of the selective D2 agonist quinpirole via a microdialysis probe into the neostriatum of urethane-anesthetized rat pups 5, 10-11, 15-16 and 21-22 days of age and adult rats. In Expt. 1, K(+)-evoked dopamine release was significantly decreased by quinpirole relative to the vehicle control group for each age in a dose-dependent manner. The maximum effect of quinpirole was not influenced by acute tolerance or the length of the experiment (Expt. 2). Finally, the effect of quinpirole (10 microM) was blocked by the addition of the selective D2 antagonist (-)-sulpiride (100 microM) to the perfusion solution (Expt. 3). These results support and extend previous research that suggests that presynaptic D2 autoreceptors in the neostriatum are able to modulate K(+)-evoked dopamine release in vivo by postnatal day 5 in the rat. |
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Authors:
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S L Andersen; R A Gazzara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research. Developmental brain research Volume: 78 ISSN: 0165-3806 ISO Abbreviation: Brain Res. Dev. Brain Res. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-20 Completed Date: 1994-07-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8908639 Medline TA: Brain Res Dev Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 123-30 Citation Subset: IM |
Affiliation:
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Department of Psychology, State University of New York at Binghamton 13902-6000. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Animals Dopamine / metabolism* Dopamine Agents / antagonists & inhibitors, pharmacology Dose-Response Relationship, Drug Drug Tolerance Ergolines / antagonists & inhibitors, pharmacology Male Microdialysis Neostriatum / drug effects, growth & development*, metabolism* Potassium / pharmacology* Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D2 / antagonists & inhibitors, drug effects, physiology* Sulpiride / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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RR07149/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 0/Ergolines; 0/Receptors, Dopamine D2; 15676-16-1/Sulpiride; 7440-09-7/Potassium; 85760-74-3/Quinpirole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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