Document Detail

The developing human preterm neonatal immune system: A case for more research in this area.
MedLine Citation:
PMID:  22926079     Owner:  NLM     Status:  Publisher    
Neonates, particularly those born prematurely, are among the most vulnerable age group for morbidity and mortality due to infections. Immaturity of the innate immune system and a high need for invasive medical procedures in the context of a preterm birth make these infants highly susceptible to common neonatal pathogens. Preterm infants who survive may also suffer permanent disabilities due to organ damage resulting from either the infection itself or from the inflammatory response generated under an oxidative stress. Infections in preterm infants continue to pose important healthcare challenges. Yet, developmental maturation events in the innate immune system that underlie their excessively high vulnerability to infection remain largely understudied. In this review article, we identify pertinent knowledge gaps that must be filled in order to orient future translational research.
Ashish Arunkumar Sharma; Roger Jen; Alison Butler; Pascal M Lavoie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  145     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  61-68     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Inc. All rights reserved.
Child & Family Research Institute, 950 west 28th Avenue, Vancouver BC, Canada V5Z4H4; Department of Medicine University of British Columbia, 2329 West Mall, Vancouver BC, Canada V6T 1ZA.
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