Document Detail

A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans.
MedLine Citation:
PMID:  20528576     Owner:  NLM     Status:  MEDLINE    
This group has invented a novel deuterohemin containing peptide deuterohemin-AlaHisThrValGluLys (DhHP-6), which has various biological activities including protection of murine ischemia reperfusion injury, improving cell survival and preventing apoptosis. It was hypothesized that DhHP-6 is beneficial on the lifespan of Caenorhabditis elegans (C. elegans) and increases their resistance to heat and oxidative stress. C. elegans were treated with different concentrations of DhHP-6. Survival time and sensitivity to heat and paraquat were investigated. The data demonstrated that the mean survival time of C. elegans was significantly increased (p < 0.05) in the DhHP-6 treated group compared with the control group. The maximum lifespan was not affected by DhHP-6 treatment. DhHP-6 improved the survival rate of C. elegans in the acute heat stress (35 degrees C) and rescued the C. elegans' sensitivity to paraquat in acute oxidative stress. Superoxide dismutase 3 (SOD-3) protein was up-regulated by DhHP-6 treatment. It was further demonstrated that stress resistance genes such as hsp-16.1, hsp-16.49 and sir-2.1 were regulated by DhHP-6. DAF-16 and SIR-2.1 genes are essential for the beneficial effect of DhHP-6. Therefore, the investigation into the beneficial effect of DhHP-6 on C. elegans' lifespan has the potential to develop novel drugs to prevent ageing.
Shuwen Guan; Pengfei Li; Jing Luo; Yuanyuan Li; Lei Huang; Guan Wang; Limin Zhu; Hongkuan Fan; Wei Li; Liping Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  813-20     Citation Subset:  IM    
Jilin University, Changchun, P R China.
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MeSH Terms
Aging / drug effects*,  genetics
Animals, Genetically Modified
Caenorhabditis elegans / drug effects*,  genetics,  physiology
Caenorhabditis elegans Proteins / biosynthesis,  genetics,  physiology
Drug Evaluation, Preclinical
Gene Expression Profiling
Gene Knockdown Techniques
Genes, Helminth
Hemin / analogs & derivatives*,  pharmacology
Hot Temperature
Longevity / drug effects,  genetics
Oligopeptides / pharmacology*
Oxidative Stress / drug effects*
Paraquat / toxicity
Sirtuins / biosynthesis,  deficiency,  genetics,  physiology
Stress, Physiological / drug effects*
Succinate Dehydrogenase / deficiency,  physiology
Transcription Factors / deficiency,  genetics,  physiology
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Oligopeptides; 0/Transcription Factors; 0/daf-16 protein, C elegans; 0/deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine; 16009-13-5/Hemin; 4685-14-7/Paraquat; EC protein, C elegans; EC Dehydrogenase; EC 3.5.1.-/SIR-2.1 protein, C elegans; EC 3.5.1.-/Sirtuins

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