| A detoxication route for acetaldehyde: metabolism of diacetyl, acetoin, and 2,3-butanediol in liver homogenate and perfused liver of rats. | |
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MedLine Citation:
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PMID: 8882713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolism of diacetyl (2,3-butanedione), acetoin (3-hydroxy-2-butanone), and 2,3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2,3-butanediol in these experiments, but acetoin and 2,3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2,3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2,3-butanediol required NADH. Acetoin and 2,3-butanediol were more readily accumulated than diacetyl in brain tissue. |
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Authors:
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M Otsuka; T Mine; K Ohuchi; S Ohmori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biochemistry Volume: 119 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1997-02-06 Completed Date: 1997-02-06 Revised Date: 2007-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Okayama University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaldehyde
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pharmacokinetics* Acetoin / metabolism* Animals Butylene Glycols / metabolism* Diacetyl / metabolism* Fatty Alcohols / metabolism Liver / metabolism* Metabolic Detoxication, Drug Perfusion Rats |
| Chemical | |
Reg. No./Substance:
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0/Butylene Glycols; 0/Fatty Alcohols; 431-03-8/Diacetyl; 513-85-9/2,3-butylene glycol; 513-86-0/Acetoin; 57419-49-5/acyloin; 75-07-0/Acetaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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