Document Detail

The determination of urinary 3-trans-hydroxyproline (3 OHP). II. Normal values in neonates, infants and preschool children.
MedLine Citation:
PMID:  2841634     Owner:  NLM     Status:  MEDLINE    
3-trans-hydroxyproline is a hydroxyproline isomer present in collagens. It is more abundant in basement membrane collagen (collagen type IV) where it can be found in a relation of 12 per 1000 amino acid residues. This implicates its probable use as a marker substance for collagen type IV metabolism. Up to now only hydrolyzed urine samples were examined for the presence of this amino acid, thus indicating total urinary excretion. We are reporting the free urinary 3 OHP content of neonates, infants and preschool children. Neonates (n = 23) showed mean excretion of 0.363 micrograms/mg creatinine (SD +/- 0.127), SEM 0.026, min. 0.197, max. 0.598. Infants (n = 11) showed mean excretion of 1.501 micrograms/mg creatinine (SD +/- 0.468), SEM 0.141, min. 0.908, max. 2.553. Preschool children (n = 16) had a mean excretion of 1.442 micrograms/mg creatinine (SD +/- 0.637), SEM 0.159, min. 0.318, max. 2.342. As determined by statistical calculations, neonates differed from infants and preschool children significantly (p less than 0.0005). Infants did not differ from preschool children, however (p less than 0.4). The reason for the low urinary excretion of 3 OHP in the neonatal period could be explained by the low enzyme activities which are physiologically observed in this developmental period in general and in the special case of a presumably low activity of the 3-prolyl-hydroxylase. Infants and preschool children presented levels 5 times higher than their neonatal mates, probably reflecting the increased 3-prolyl-hydroxylase activity which in turn is a marker of collagen synthesis.
M T Weiss; M Weninger; J Häusler; G Lubec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pädiatrie und Pädologie     Volume:  23     ISSN:  0030-9338     ISO Abbreviation:  Padiatr Padol     Publication Date:  1988  
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0022370     Medline TA:  Padiatr Padol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
University of Vienna, Department of Paediatrics.
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MeSH Terms
Child Development*
Child, Preschool
Collagen / metabolism
Hydroxyproline / urine*
Infant, Newborn
Procollagen-Proline Dioxygenase / physiology
Reference Values
Reg. No./Substance:
51-35-4/Hydroxyproline; 9007-34-5/Collagen; EC Dioxygenase; EC, 2-oxoglutarate 3-dioxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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