| The determination of trimazosin and its metabolite CP23445 in whole blood by high performance liquid chromatography using fluorescence detection. | |
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MedLine Citation:
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PMID: 6536811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sensitive and specific assay for trimazosin and its metabolite CP23445 is described. The method employs reverse-phase high performance liquid chromatography (HPLC) with fluorescence detection. The limit of detection of the assay is 1 ng/ml whole blood for trimazosin and 0.5 ng/ml for CP23445. The coefficient of variation for trimazosin and CP23445 over a typical calibration size is 5.4% and 4.9%, respectively. Various drugs that may be coadministered with trimazosin are shown not to interfere in the assay. The method has been extensively employed to study the pharmacokinetics of trimazosin and CP23445, both in man and in animals. |
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Authors:
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M A Hughes; P A Meredith; H L Elliott |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacological methods Volume: 12 ISSN: 0160-5402 ISO Abbreviation: J Pharmacol Methods Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806596 Medline TA: J Pharmacol Methods Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Humans Metabolic Clearance Rate Piperazines / blood*, metabolism Spectrometry, Fluorescence |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 35795-16-5/trimazosin; 88321-10-2/1-hydroxytrimazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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