Document Detail


The determination of additive effect and intraocular pressure lowering effects of 0.05% bromocriptine and 0.25% timolol.
MedLine Citation:
PMID:  9112164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been confirmed that topically applied bromocriptine has a satisfactory intraocular pressure (IOP) lowering effect without serious ocular or systemic side effects. We compared the IOP lowering effects of 0.05% bromocriptine and 0.25% timolol and determined whether they have an additive effect in lowering IOP in normal volunteers. In a double-blind, randomised, prospective, single-dose study, we measured IOP in 24 ocular normotensive subjects before (baseline) and 2, 4 and 6 hours after topical instillation of the following drugs: timolol and bromocriptine alone (n: 14), timolol+bromocriptine, timolol+placebo, bromocriptine+placebo (n: 10). Both bromocriptine and timolol have a significant IOP lowering effect (p < 0.01) compared with the baseline value during the study period. There were no significant differences in IOP lowering effect between timolol and bromocriptine at 2 and 4 hours (p > 0.05), but timolol was more efficacious than bromocriptine at 6 hours (p < 0.05). An additive effect in lowering IOP was not found. Although timolol and bromocriptine have no additive effect in lowering IOP, topically applied bromocriptine may be used in the treatment of glaucoma.
Authors:
O Elibol; C Güler; K Arici; A Topalkara; S Demircan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International ophthalmology     Volume:  20     ISSN:  0165-5701     ISO Abbreviation:  Int Ophthalmol     Publication Date:    1996-1997
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-5     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Cumhuriyet University, School of Medicine, Sivas, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adrenergic beta-Antagonists / administration & dosage*
Adult
Bromocriptine / administration & dosage*
Dopamine Agonists / administration & dosage*
Double-Blind Method
Drug Evaluation
Drug Synergism
Follow-Up Studies
Humans
Intraocular Pressure / drug effects*
Ophthalmic Solutions
Prospective Studies
Reference Values
Safety
Timolol / administration & dosage*
Tonometry, Ocular / methods
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Dopamine Agonists; 0/Ophthalmic Solutions; 25614-03-3/Bromocriptine; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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