Document Detail


The determinants of response to diltiazem in hypertension.
MedLine Citation:
PMID:  1914368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined factors (blood pressure, plasma renin activity, and age) influencing the antihypertensive response in essential hypertensive patients given 240 mg/day of slow-release diltiazem in an unblinded study after a placebo run-in period. Subjects provided a range of diastolic blood pressures (90 to 115 mm Hg), of age (31 to 70 years), and of plasma renin activity (0.1 to 2.7 ng angiotensin I/ml/hr) on a 70 to 150 mEq sodium diet. Blood pressure, plasma renin activity, and plasma diltiazem concentrations were measured after the first (n = 21) and final dose (n = 19) of 120 mg diltiazem, twice daily for 4 weeks. Multiple linear stepwise regression of change in blood pressure versus age, plasma renin activity, and baseline blood pressure showed baseline blood pressure was the only predictor of response (p = 0.0002). For each increase of 10 mm Hg in baseline pressure there was a 7 mm Hg greater decrease in diastolic blood pressure. We conclude that patient age and plasma renin activity are not clinically significant predictors of antihypertensive response to diltiazem in hypertension.
Authors:
A M Shepherd; C LeForce; G D Park; R S Hoop; S Weir
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  50     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-25     Completed Date:  1991-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-49     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Blood Pressure / drug effects
Delayed-Action Preparations
Diltiazem / administration & dosage,  pharmacokinetics,  therapeutic use*
Female
Half-Life
Humans
Hypertension / blood,  drug therapy*,  urine
Male
Metabolic Clearance Rate
Middle Aged
Regression Analysis
Renin / blood
Sodium / urine
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 42399-41-7/Diltiazem; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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