Document Detail

The determinants of plasma beta-carotene: interaction between smoking and other lifestyle factors.
MedLine Citation:
PMID:  8730610     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of cigarette smoking on the relationship between dietary intake and circulating levels of beta-carotene. DESIGN: A secondary analysis of data collected for the Diet and Nutritional Survey of British Adults by The Department of Health and The Ministry of Agriculture, Fisheries and Food; the study was a cross-sectional survey of a representative sample of the British population. SETTING: The study was conducted on a free living adult (16-64 years of age) population resident in Great Britain. SUBJECTS: 1483 subjects completed a seven day weighed inventory and provided a blood sample. RESULTS: Smokers had statistically significantly lower dietary intakes and circulating levels of beta-carotene than non-smokers. At the same level of dietary intake, smokers were more likely to have lower circulating levels than non-smokers. For every 1000 micrograms change in dietary intake, there was a 0.01 mumol/l change in plasma beta-carotene in smokers and a 0.04 mumol/l change in non-smokers. The effect of smoking on circulating levels of beta-carotene persisted after adjusting for other factors. CONCLUSIONS: The results suggest that smoking places extra demands on the host; the higher risk of heart disease for smokers may be due to a combination of an increased inflammatory response, reduced host defences, and increased levels of circulating LDL. Failure to take account of the interaction between risk factors may distort the estimates of the relative importance of each factor when considered in isolation.
B M Margetts; A A Jackson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  50     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  236-8     Citation Subset:  IM    
Wessex Institute of Public Health Medicine, University of Southampton, Southampton General Hospital, UK.
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MeSH Terms
Carotenoids / administration & dosage,  blood*
Cross-Sectional Studies
Data Collection
Diet / standards
Great Britain
Life Style*
Middle Aged
Nutrition Surveys
Regression Analysis
Smoking* / blood
beta Carotene
Reg. No./Substance:
36-88-4/Carotenoids; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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