Document Detail

The detection of minimal residual disease in acute lymphoblastic leukaemia.
MedLine Citation:
PMID:  1633509     Owner:  NLM     Status:  MEDLINE    
The detection of minimal residual disease in acute lymphoblastic leukaemia (ALL) can be achieved by assessing leukaemia-specific features at a cellular, chromosomal or molecular level. The application of the polymerase chain reaction to the amplification of leukaemia-specific chromosomal translocations and clone-specific immunoglobulin and T-cell receptor gene rearrangements allows assessment of the majority of cases of ALL. The sensitivity of detection of this technique is around one leukaemia cell in 10(5) normal marrow cells. A comparative review of the advantages and pitfalls of the different methods of detecting minimal disease is presented. The clinical relevance of such detection is discussed, with early results suggesting that this may have predictive value for future disease relapse.
M N Potter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Blood reviews     Volume:  6     ISSN:  0268-960X     ISO Abbreviation:  Blood Rev.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-26     Completed Date:  1992-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  68-82     Citation Subset:  IM    
Department of Haematology-Oncology, Royal Hospital for Sick Children, Bristol, UK.
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MeSH Terms
Immunoglobulin Heavy Chains / genetics
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*,  genetics,  pathology
Receptors, Antigen, T-Cell / genetics
Translocation, Genetic / genetics
Reg. No./Substance:
0/Immunoglobulin Heavy Chains; 0/Receptors, Antigen, T-Cell

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