| On the detection of imprinted quantitative trait loci in experimental crosses of outbred species. | |
| | |
MedLine Citation:
|
PMID: 12072486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this article, the quantitative genetic aspects of imprinted genes and statistical properties of methods to detect imprinted QTL are studied. Different models to detect imprinted QTL and to distinguish between imprinted and Mendelian QTL were compared in a simulation study. Mendelian and imprinted QTL were simulated in an F2 design and analyzed under Mendelian and imprinting models. Mode of expression was evaluated against the H(0) of a Mendelian QTL as well as the H(0) of an imprinted QTL. It was shown that imprinted QTL might remain undetected when analyzing the genome with Mendelian models only. Compared to testing against a Mendelian QTL, using the H(0) of an imprinted QTL gave a higher proportion of correctly identified imprinted QTL, but also gave a higher proportion of false inference of imprinting for Mendelian QTL. When QTL were segregating in the founder lines, spurious detection of imprinting became more prominent under both tests, especially for designs with a small number of F1 sires. |
| | |
Authors:
|
Dirk-Jan de Koning; Henk Bovenhuis; Johan A M van Arendonk |
Related Documents
:
|
22457686 - Irritable bowel syndrome treatment: cognitive behavioral therapy versus medical treatment. 21326666 - Setting up a medical clinical office. 21436706 - Religious and spiritual beliefs of gynecologic oncologists may influence medical decisi... 3101096 - Autodestruction and nonexistence: two distinct aspects of the death drive. 9493486 - The changes in sexual functioning questionnaire (csfq): development, reliability, and v... 18370986 - On-call specialists and higher level of care transfers in california emergency departme... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Genetics Volume: 161 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 2002 Jun |
Date Detail:
|
Created Date: 2002-06-19 Completed Date: 2003-01-10 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
|
Languages: eng Pagination: 931-8 Citation Subset: IM |
Affiliation:
|
Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands. johan.vanarendonk@alg.vf.wag-ur.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Computer Simulation Crosses, Genetic* Data Interpretation, Statistical Genomic Imprinting* Models, Genetic Quantitative Trait Loci* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Precision and high-resolution mapping of quantitative trait loci by use of recurrent selection, back...
Next Document: Characterization of vesicular stomatitis virus recombinants that express and incorporate high levels...