Document Detail

The detection and discrimination of malignant and benign focal hepatic lesions: T2 weighted vs diffusion-weighted MRI.
MedLine Citation:
PMID:  20959371     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the use of diffusion-weighted imaging (DWI) for the detection and characterisation of focal hepatic lesions compared with the use of T(2) weighted imaging.
METHOD: 45 patients with 97 hepatic lesions (51 malignant lesions and 46 benign lesions) were included in this retrospective study. Malignant hepatic lesions included 12 hepatocellular carcinomas, 26 metastases and 13 intrahepatic cholangiocarcinomas. Benign hepatic lesions included 19 haemangiomas and 27 cysts. The MRI protocol for the upper abdomen included T(2) weighted images, in- and opposed-phase T(1) weighted images and dynamic T(1) weighted images. Breath-hold fat-suppressed single-shot echo planar DWI was performed with the following parameters: 1338/66; b factors, 0, 50 and 800 s mm(-2). Two independent observers reviewed the T(2) weighted images and the DWI to detect and to characterise the hepatic lesions.
RESULTS: For detection of malignant hepatic lesions, the use of DWI showed a significantly higher detection rate than the use of T(2) weighted images (p<0.05). However, there was no significant difference between the use of DWI and T(2) weighted images for benign hepatic lesions. For the differentiation between malignant and benign hepatic lesions, there was no significant difference in sensitivity, specificity and accuracy between the use of T(2) weighted images and the use of DWI.
CONCLUSION: The use of DWI was better for the detection of malignant hepatic lesions than the use of T(2) weighted images. However, for detection of benign hepatic lesions and characterisation of hepatic lesions, the use of DWI was equivalent to the use of T(2) weighted images.
D M Yang; G H Jahng; H C Kim; W Jin; C W Ryu; D H Nam; Y K Lee; S Y Park
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-19
Journal Detail:
Title:  The British journal of radiology     Volume:  84     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-05-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  AIM; IM    
Department of Radiology, Kyung Hee University East-West Neo Medical Center, 149 Sangil-Dong, Gangdong-Gu, Seoul, Korea.
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MeSH Terms
Bile Duct Neoplasms / diagnosis,  pathology
Carcinoma, Hepatocellular / diagnosis*,  pathology
Cholangiocarcinoma / diagnosis,  pathology
Contrast Media / diagnostic use
Cysts / diagnosis*,  pathology
Diffusion Magnetic Resonance Imaging / instrumentation,  methods*
Hemangioma / diagnosis*,  pathology
Liver Neoplasms / diagnosis*,  pathology
Middle Aged
Observer Variation
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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