Document Detail

The detection of diminished ovarian reserve in infertile women.
MedLine Citation:
PMID:  9757994     Owner:  NLM     Status:  MEDLINE    
Women in their mid to late 30s and early 40s with infertility constitute the largest portion of the total infertility population. These women frequently undergo multiple testing, and most will require expensive and invasive therapies, including assisted reproductive technologies, with markedly reduced pregnancy rates in those older than 40. These women also have a higher incidence of pregnancy loss even after documentation of fetal cardiac activity by ultrasonography. Identifying those women who have a very low chance of pregnancy (and a high chance of pregnancy loss) with their own gametes presents a daily challenge to the practicing clinician, especially before embarking on expensive treatments. This article reviews the contemporary investigation of reproductive aging with basal and provocative tests. Women with markedly diminished ovarian reserve should be counseled on their low chances of conception with their own gametes, even with assisted reproductive technologies.
F I Sharara; R T Scott; D B Seifer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  804-12     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Aging / physiology
Fertilization in Vitro
Follicle Stimulating Hormone / blood
Infertility, Female / diagnosis*,  physiopathology*,  therapy
Ovary / physiopathology*
Ovulation Induction
Pregnancy Rate
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

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