| The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. | |
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MedLine Citation:
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PMID: 11869858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate the role of cardiotropic viruses, including adenovirus, cytomegalovirus (CMV), enterovirus and parvovirus, in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy is characterized by a gradual loss of myocytes, inflammatory infiltrates and replacement by fatty and fibrous tissue. It has been speculated that ARVD/C is a sequela of viral myocarditis in some patients, and the role of the coxsackievirus B3 has been debated. METHODS: Myocardial samples from 12 patients with ARVD/C were analyzed by polymerase chain reaction for the presence of cardiotropic viruses. RESULTS: Enteroviral sequences were detected in seven patients and adenovirus type 5 in another two patients. During the same period, 215 control samples were analyzed in which only CMV (n = 2) and enterovirus (n = 1) were detected. This suggests a link between ARVD/C and the presence of viral genome (enterovirus or adenovirus) in the myocardium. CONCLUSIONS: We report that cardiotropic viruses are more frequently identified in patients with ARVD/C than in control subjects. However, the role of these viruses in ARVD/C pathogenesis remains unknown. |
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Authors:
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Neil E Bowles; Jiyuan Ni; Frank Marcus; Jeffrey A Towbin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 39 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-28 Completed Date: 2002-03-20 Revised Date: 2009-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 892-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. nbowles@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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isolation & purification*,
physiology* Adolescent Adult Arrhythmogenic Right Ventricular Dysplasia / physiopathology*, virology* Child Child, Preschool Cytomegalovirus / isolation & purification*, physiology* Enterovirus / isolation & purification*, physiology* Female Heart / physiopathology*, virology* Humans Male Parvovirus / isolation & purification*, physiology* Polymerase Chain Reaction |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2009 Apr 28;53(17):1570-1; author reply 1571-2
[PMID:
19389573
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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