Document Detail

The detection of basal cell determinants in human basal cell carcinomas using two different monoclonal antibodies.
MedLine Citation:
PMID:  2448989     Owner:  NLM     Status:  MEDLINE    
This report deals with the reaction pattern(s) of two monoclonal antibodies (MoAbs) with normal skin and basal cell carcinomas (BCC). Using indirect immunoperoxidase (IIP) and indirect immunofluorescence (IIF) techniques, MoAb 12 G7 was observed to react with a determinant related to the cell membrane of the epidermal basal cells. In the IIP technique MoAb 12 G7 showed a positive reaction with 32 out of 34 BCC (94%), while in IIF all the 14 BCC that were studied were positive. In most cases only the cells at the periphery of the tumour nests were stained. MoAb 253 B7 reacted with cytoplasmic determinant(s) of the epidermal basal cells both in the IIF as well as in the IIP techniques. Using the IIP technique only 5 out of 34 BCC (15%) showed a positive reaction with this MoAb. Four of the 5 positively staining tumours showed aggressive histological features. Using IIF technique only 2 out of 14 BCC were positive. The results presented in this communication are discussed with regard to the possible expression of selective differentiation and tumor-associated determinant(s) in BCC.
J M Habets; B Tank; V D Vuzevski; E C van Reede; E Stolz; T van Joost
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  67     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-14     Completed Date:  1988-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / diagnostic use
Carcinoma, Basal Cell / immunology,  pathology*
Epitopes / analysis*
Fluorescent Antibody Technique
Immunoenzyme Techniques
Middle Aged
Skin Neoplasms / immunology,  pathology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Epitopes

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