| The detection of basal cell determinants in human basal cell carcinomas using two different monoclonal antibodies. | |
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MedLine Citation:
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PMID: 2448989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report deals with the reaction pattern(s) of two monoclonal antibodies (MoAbs) with normal skin and basal cell carcinomas (BCC). Using indirect immunoperoxidase (IIP) and indirect immunofluorescence (IIF) techniques, MoAb 12 G7 was observed to react with a determinant related to the cell membrane of the epidermal basal cells. In the IIP technique MoAb 12 G7 showed a positive reaction with 32 out of 34 BCC (94%), while in IIF all the 14 BCC that were studied were positive. In most cases only the cells at the periphery of the tumour nests were stained. MoAb 253 B7 reacted with cytoplasmic determinant(s) of the epidermal basal cells both in the IIF as well as in the IIP techniques. Using the IIP technique only 5 out of 34 BCC (15%) showed a positive reaction with this MoAb. Four of the 5 positively staining tumours showed aggressive histological features. Using IIF technique only 2 out of 14 BCC were positive. The results presented in this communication are discussed with regard to the possible expression of selective differentiation and tumor-associated determinant(s) in BCC. |
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Authors:
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J M Habets; B Tank; V D Vuzevski; E C van Reede; E Stolz; T van Joost |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 67 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-03-14 Completed Date: 1988-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 391-8 Citation Subset: IM |
Affiliation:
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Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Monoclonal / diagnostic use Carcinoma, Basal Cell / immunology, pathology* Epitopes / analysis* Fluorescent Antibody Technique Humans Immunoenzyme Techniques Middle Aged Skin Neoplasms / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Epitopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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