Document Detail


The detection of antibacterial actions of whole herb tinctures using luminescent Escherichia coli.
MedLine Citation:
PMID:  17661335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two whole cell Escherichia coli luminescent biosensors were used to determine the antibacterial actions of 16 herbal tinctures. These bioassays can detect genotoxic (strain DPD2794) and general oxidative stress (DE135) events when challenged with antibacterial substances. Many of the herbal tinctures were active against these Gram-negative bacteria, affecting their metabolism without, in some cases, arresting cell growth or causing cell death. Antibacterial activity ranged from undetectable for Curcuma longa, Cinnamomum zeylanicum and Apium graveolens to highly effective against both E. coli strains in the case of Rosmarinus officinalis. Some of the results were unexpected. Althaea officinalis affected microbial metabolism in spite of the lack of literature precedent, and Cinnamomum zeylanicum did not appear to be antimicrobial, as claimed in some literature. It is concluded that studies using luminescent bacterial biosensors can provide important new insights into the potency and modes of the lethal and sub-lethal antibacterial action of whole herbs, and thereby provide crucial evidence for efficacy demanded by modern science and medicine.
Authors:
Kathryn Watt; Nick Christofi; Rodney Young
Related Documents :
22760225 - Arsenic bioremediation potential of a new arsenite-oxidizing bacterium stenotrophomonas...
18567575 - Resistance mapping and mode of action of a novel class of antibacterial anthranilic aci...
2666415 - Translational frameshifts induced by mutant species of the polypeptide chain elongation...
22544265 - Mext functions as a redox-responsive regulator modulating disulfide stress resistance i...
15795085 - A real-time pcr assay to detect the panton valentine leukocidin toxin in staphylococci:...
14605185 - Prevalence of group a streptococcal carriers in asymptomatic children and clonal relate...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  21     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1193-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Affiliation:
Pollution Research Unit, Applied Research Centre for Health, Environment and Society (ARCHES), Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / analysis*,  pharmacology
Cookery
Escherichia coli / drug effects*,  genetics
Luminescent Proteins / analysis*,  genetics
Organisms, Genetically Modified
Plant Extracts / chemistry*,  pharmacology
Plants, Medicinal / chemistry*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Luminescent Proteins; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cytoprotective effects of Bergenia ciliata Sternb, extract on gastric ulcer in rats.
Next Document:  Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I.