Document Detail


The detection of anti-D in Rho (D)-negative infants born of Rho (D)-positive mothers.
MedLine Citation:
PMID:  818607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has not been determined whether Rho (D)-negative infants born of Rho (D)-positive mothers are sensitized during gestation or during parturition. Sensitization before use precludes the efficacious use of human Rho immune globulin as a prophylactic. The purpose of the present study is to identify the time of sensitization. Cord blood was collected from the placentas of 68 Rho (D)-negative infants whose mothers were Rho (D)-positive. Sixty-three of the 68 infants had one blood sample obtained between 1 and 9 months later. The paired samples were analyzed for anti-D by standard Coombs test and by automated antibody detection techniques. With the technique of automated antibody detection, we have been unable to demonstrate antibody in cord blood of the Rho (D)-negative infants of whom at least 7 of 63 (11%) had detectable anti-D between 1 and 9 months of age. These data show that Rho (D)-negaitve infants do not have detectable antibody at birth but may develop detectable anti-D in the first months of life. This observation suggests that the sensitizing dose of Rho (D) antigen occurs at parturition rather than during gestation.
Authors:
F W Bowen; M Renfield
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  10     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Anti-Idiotypic / analysis
Antibody Formation
Clinical Trials as Topic
Erythroblastosis, Fetal / prevention & control
Female
Fetal Blood / immunology
Humans
Immunoglobulin D / analysis,  therapeutic use
Infant
Infant, Newborn*
Isoantibodies / analysis*
Labor, Obstetric
Male
Mice
Pregnancy
Rh-Hr Blood-Group System*
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin D; 0/Isoantibodies; 0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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