Document Detail


The design of the prenatal determinants of schizophrenia study.
MedLine Citation:
PMID:  10885629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper describes the Prenatal Determinants of Schizophrenia (PDS) Study; three companion papers report the first results. The PDS Study was designed to study early antecedents of schizophrenia in a birth cohort of 1959-1967 for whom a wealth of archived prenatal data--including maternal sera--was available. Making use of the registries of a health plan into which the cohort was born, we ascertained and then diagnosed 71 cases of schizophrenia and spectrum disorders in the cohort. We describe herein the available prenatal data, the process of case diagnosis, and the strategies used to analyze prenatal determinants of schizophrenia in this cohort. Data are presented that bear on the main sources of potential bias and are important to understanding the strengths and limitations of this unique data set.
Authors:
E S Susser; C A Schaefer; A S Brown; M D Begg; R J Wyatt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  26     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-03     Completed Date:  2000-11-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-73     Citation Subset:  IM    
Affiliation:
Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York State Psychiatric Institute, College of Physicians and Surgeons, New York 10032, USA. ess8@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Bias (Epidemiology)
Cohort Studies
Female
Humans
Male
Pregnancy
Prenatal Care
Prenatal Exposure Delayed Effects*
Registries
Research Design
Schizophrenia / epidemiology,  etiology*
Grant Support
ID/Acronym/Agency:
1R01MH-53147/MH/NIMH NIH HHS; 5P20MH-50727/MH/NIMH NIH HHS; IK20MH 01206/MH/NIMH NIH HHS

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