| The design of clinical trials with antibiotics. | |
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MedLine Citation:
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PMID: 2226485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical trials to test antibiotics are normally of a less than satisfactory quality. Examples of common errors in the design and execution of trials with antibiotics are inclusion of too few patients to allow conclusions to be drawn, open uncontrolled design leading to a risk of considerable investigator bias, and inclusion of heterogeneous patient samples. This article suggests minimum requirements for antibiotic studies. Guidelines for such trials are needed and should have the widest possible international application in order to permit studies involving centres in various countries and to reduce the costs for development of new drugs. |
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Authors:
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S R Norrby |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 9 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-12-12 Completed Date: 1990-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: GERMANY |
Other Details:
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Languages: eng Pagination: 523-9 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, Lund University Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Bacterial Infections / drug therapy* Clinical Trials as Topic Drug Evaluation Epidemiologic Methods Health Planning Guidelines Humans United States |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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