Document Detail

The descent of memory T cells.
MedLine Citation:
PMID:  21251009     Owner:  NLM     Status:  In-Data-Review    
Our T cell repertoire is shaped by antigen encounter. From a naive T cell pool that contains millions of different T cells with unknown specificities, pathogen infection leads to selection of those T cells that can detect pathogen-derived antigens. Following clearance of infection, a population of memory T cells remains and protects the individual from severe reinfection. A central question in the field has been how the generation of long-lived memory T cells, versus short-lived ("terminally differentiated") T cells, is controlled. In this review we discuss the models that have been put forward to explain the generation of memory T cells after infection and the experimental evidence supporting these hypotheses. Based on the available data we propose a new model that stipulates that during immune responses T cells do not acquire different fates that determine their subsequent long-term survival but rather T cells assume different states that simply reflect the likelihood of future survival, states that can still be modulated by external signals.
Carmen Gerlach; Jeroen W J van Heijst; Ton N M Schumacher
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Publication Detail:
Type:  Journal Article     Date:  2011-01-14
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1217     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-53     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
The Netherlands Cancer Institute, Department of Immunology, Amsterdam, The Netherlands.
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