Document Detail

A dermatomyositis and scleroderma overlap syndrome with a remarkable high titer of anti-exosome antibodies.
MedLine Citation:
PMID:  19132155     Owner:  NLM     Status:  MEDLINE    
An overlap syndrome of dermatomyositis and scleroderma is reported. The case corresponded to a 27-year-old female with a clinical picture of 14 months evolution, characterized by proximal muscles weakness, erythematous rash in wrists, knees, ankles, Gottron sign, heliotrope periorbital rash and dysphagia. A muscle biopsy was compatible with dermatomyositis; meanwhile the skin biopsy was compatible with scleroderma. Muscle enzymes were increased. Interestingly, the antinuclear antibody determination in HEp-2 cells was positive with a remarkable titer of 81,920 exhibiting a nucleolar pattern. Anti-Jo1 antibody was negative, but anti-PM/Scl-100 positive. The patient received methylprednisolone and cyclophosphamide pulses, with gradual improvement. Present report constitutes a case of overlap dermatomyositis-scleroderma syndrome, with anti-PM/Scl autoantibodies (anti-exosome). The remarkable of this case was the exceptional high antinucleolar antibody titer.
R Gutiérrez-Ramos; V Gonz Lez-Díaz; M G Pacheco-Tovar; A López-Luna; E Avalos-Díaz; R Herrera-Esparza
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Reumatismo     Volume:  60     ISSN:  0048-7449     ISO Abbreviation:  Reumatismo     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401302     Medline TA:  Reumatismo     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  296-300     Citation Subset:  IM    
Department of Immunology, Centro de Biología Experimental, Universidad Autónoma de Zacatecas, Zac. 98040, México.
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MeSH Terms
Autoantibodies / blood*
Dermatomyositis / blood*,  immunology
Exosomes / immunology*
Scleroderma, Systemic / blood*,  immunology
Reg. No./Substance:

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