| A dermatomyositis and scleroderma overlap syndrome with a remarkable high titer of anti-exosome antibodies. | |
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MedLine Citation:
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PMID: 19132155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An overlap syndrome of dermatomyositis and scleroderma is reported. The case corresponded to a 27-year-old female with a clinical picture of 14 months evolution, characterized by proximal muscles weakness, erythematous rash in wrists, knees, ankles, Gottron sign, heliotrope periorbital rash and dysphagia. A muscle biopsy was compatible with dermatomyositis; meanwhile the skin biopsy was compatible with scleroderma. Muscle enzymes were increased. Interestingly, the antinuclear antibody determination in HEp-2 cells was positive with a remarkable titer of 81,920 exhibiting a nucleolar pattern. Anti-Jo1 antibody was negative, but anti-PM/Scl-100 positive. The patient received methylprednisolone and cyclophosphamide pulses, with gradual improvement. Present report constitutes a case of overlap dermatomyositis-scleroderma syndrome, with anti-PM/Scl autoantibodies (anti-exosome). The remarkable of this case was the exceptional high antinucleolar antibody titer. |
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Authors:
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R Gutiérrez-Ramos; V Gonz Lez-Díaz; M G Pacheco-Tovar; A López-Luna; E Avalos-Díaz; R Herrera-Esparza |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Reumatismo Volume: 60 ISSN: 0048-7449 ISO Abbreviation: Reumatismo Publication Date: 2008 Oct-Dec |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401302 Medline TA: Reumatismo Country: Italy |
Other Details:
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Languages: eng Pagination: 296-300 Citation Subset: IM |
Affiliation:
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Department of Immunology, Centro de Biología Experimental, Universidad Autónoma de Zacatecas, Zac. 98040, México. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood* Dermatomyositis / blood*, immunology Exosomes / immunology* Female Humans Scleroderma, Systemic / blood*, immunology Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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