| The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. | |
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MedLine Citation:
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PMID: 20804756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells can not only sense the type of extracellular matrix (ECM) protein that is present in the microenvironment, but they can also sense its density. Here, we investigated the effects of ECM protein density on adipokine secretion and insulin signaling in adipocytes. To this end, 3T3-L1 adipocytes were cultured on the surface of polyacrylamide gels that were coated with gradient densities of a collagen type I and fibronectin mixture. We found that high density ECM causes a decrease in insulin signaling and adiponectin secretion, whereas the secretion of monocyte chemoattractant protein-1 (MCP-1) was increased via the activation of nuclear factor-κB (NF-κB). These results indicate that the density of the ECM directly regulates the inflammatory response and insulin sensitivity of adipocytes. |
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Authors:
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Qinkai Li; Akiko Hata; Chisato Kosugi; Nananko Kataoka; Makoto Funaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-29 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4145-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan. lqk@clin.med.tokushima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Adipocytes / metabolism* Adiponectin / metabolism Animals Chemokine CCL2 / metabolism Extracellular Matrix Proteins / metabolism* Inflammation / metabolism* Insulin / metabolism* Insulin Resistance Mice NF-kappa B / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Adipoq protein, mouse; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Extracellular Matrix Proteins; 0/Insulin; 0/NF-kappa B |
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