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The dengue virus nonstructural protein 1 (NS1) increases NF-κB transcriptional activity in HepG2 cells.
MedLine Citation:
PMID:  21424730     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dengue virus nonstructural protein 1 (NS1) is a glycoprotein involved in viral RNA replication. NS1 associates with host cell proteins and can be found in lipid raft domains on the host cell surface, suggesting an involvement in signal transduction events. In this work, we observed that NS1 expression in HepG2 cells increases nuclear translocation of NF-κB p65 protein, which was paralleled by DNA-protein complex formation. Luciferase assays showed an increase in NF-κB transcriptional activities in NS1-expressing cells when compared to parental cells. NS1 may enhance NF-κB function in host cells and contribute to the pathogenesis of dengue.
Authors:
Breno M Silva; Lirlândia P Sousa; Alessandra C Gomes-Ruiz; Flávia G G Leite; Mauro M Teixeira; Flávio G da Fonseca; Paulo F P Pimenta; Paulo C P Ferreira; Erna G Kroon; Cláudio A Bonjardim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Archives of virology     Volume:  -     ISSN:  1432-8798     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil, brenomello@pq.cnpq.br.
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