Document Detail

A demographic approach to the assessment of Down syndrome screening performance.
MedLine Citation:
PMID:  9267894     Owner:  NLM     Status:  MEDLINE    
The aim of this article is to examine the performance of screening for fetal Down syndrome (DS) in the context of demographic variation in time and place, using population and fertility data for several European countries. Two screening approaches are distinguished: one on the basis of maternal serum screening with human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in combination with maternal age, and one on the basis of maternal age only. Screening performance, as measured by detection and false-positive ratios, is shown to be the result of the screening approach chosen and of the demographic characteristics of the population under consideration. A proper distinction between these two determinants of DS screening performance should be made, in order to distinguish between an improvement in screening performance that is brought about by a new screening approach and an improvement that is brought about by demographic change. We recommend that measures of DS screening performance be standardized for demographic variation. The methodology and demographic data presented in this article can be used for this purpose.
W J van der Veen; J R Beekhuis; M C Cornel; A Mantingh; H E de Walle; B T de Wolf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  17     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-02     Completed Date:  1997-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  717-24     Citation Subset:  IM    
Population Research Centre, University of Groningen, The Netherlands.
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MeSH Terms
Chorionic Gonadotropin / blood
Down Syndrome / diagnosis*
False Positive Reactions
Maternal Age
Middle Aged
Prenatal Diagnosis / methods*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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