| On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. | |
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MedLine Citation:
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PMID: 15363569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the degree of ejaculation delay induced by on-demand treatment with 20 mg paroxetine and 25 mg clomipramine and to assess the type and severity of non-sexual side-effects of treatment at the day of and the day after treatment with these drugs. METHOD: A randomized, double-blind, fixed-dose, on-demand study in 30 men with lifelong premature ejaculation was performed. During a 1-month baseline period and a 4-week drug treatment period patients assessed the intravaginal ejaculation latency time (IELT) at home with a stopwatch. Only men with an IELT <1 min were randomly assigned to drug treatment. Patients assessed the drug coitus interval time (DCIT) and used the UKU side effect scale questionnaire at baseline, the day of and the day after intercourse. RESULTS: On-demand treatment with 25 mg clomipramine, with a mean DCIT of 5.14 h, led to a 4.05 (95%CI: 3.26-5.02) fold-increase of the IELT. On-demand treatment with 20 mg paroxetine, with a mean DCIT of 5.39 h, led to a 1.41 (95%CI: 1.22-1.63) fold-increase of the IELT. Both drugs had a high incidence of non-sexual side effects at the coitus day and the next day. At the day of coitus paroxetine led to significant sleepiness and yawning compared to clomipramine. At the day after coitus clomipramine induced significant nausea compared to paroxetine. CONCLUSION: On-demand treatment with 25 mg clomipramine led to a clinical relevant ejaculation delay. In contrast, 20 mg paroxetine had no clinical relevant ejaculation delay in men with lifelong premature ejaculation with an IELT of less than 1 minute. Both drugs exert mostly mild yet annoying non-sexual side effects both at the coitus day and the next day. |
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Authors:
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Marcel D Waldinger; Aeilko H Zwinderman; Berend Olivier |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European urology Volume: 46 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-14 Completed Date: 2005-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 510-5; discussion 516 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Neurosexology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands. md@waldinger.demon.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antidepressive Agents / pharmacology* Clomipramine / pharmacology* Cluster Analysis Coitus Double-Blind Method Ejaculation / drug effects*, physiology Humans Male Middle Aged Paroxetine / pharmacology* Serotonin Uptake Inhibitors / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine; 61869-08-7/Paroxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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