| On-demand PPI requirements in patients with endoscopy-negative GERD. | |
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MedLine Citation:
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PMID: 15365398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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GOALS: To evaluate the need for on-demand treatment with proton pump inhibitor in patients with endoscopy-negative GERD. BACKGROUND: Studies indicate that on-demand therapy is suitable for patients without mucosal disease, but the need for PPI in a monotherapy situation is not known. STUDY: Forty-one patients with heartburn and/or acid reflux of more than 3 months duration participated in the study. All were endoscopy-negative and had responded positive to a test with lansoprazole 60 mg x 1 for 7 days. Twenty-four hour pH monitoring was attempted in all, but failed in 4. Twenty-eight had pH <4 more than 4% of the time, 9 had less. During a 3-month period, the patients were allowed to take 1 capsule 30 mg lansoprazole on-demand, maximum 2 capsules a day. The remaining capsules were counted monthly. RESULTS: In the 3-month period, the median mean daily consumption was 1.06 capsule (95% CI: 0072-1.09). No significant difference was found between those with normal or abnormal 24-hour pH-metry. Sixty-three percent used 6 or more capsules a week. CONCLUSION: Patients with longstanding negative-endoscopy reflux disease, whether abnormal or normal 24-hour pH-metry, have symptoms that demand effective therapy. Using PPI on-demand as monotherapy, most patients will need 1 capsule per day. |
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Authors:
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Paul Juul-Hansen; Andreas Rydning |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 38 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-14 Completed Date: 2005-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 746-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Akershus University Hospital, Nordbyhagen, Norway. paul.juul-hansen@klinmed.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Adult Aged Anti-Ulcer Agents / administration & dosage, therapeutic use* Capsules Drug Administration Schedule Endoscopy, Gastrointestinal Female Gastroesophageal Reflux / complications, drug therapy* Heartburn / drug therapy, etiology Humans Hydrogen-Ion Concentration / drug effects Male Middle Aged Monitoring, Physiologic Omeprazole / administration & dosage, analogs & derivatives*, therapeutic use* Prospective Studies Proton Pumps / antagonists & inhibitors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Capsules; 0/Proton Pumps; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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