Document Detail

Is delta-aminolevulinic acid dehydratase activity in bivalves from south-west Iberian Peninsula a good biomarker of lead exposure?
MedLine Citation:
PMID:  18381224     Owner:  NLM     Status:  MEDLINE    
The coast of Huelva is considered as a heavily contaminated area where the Tinto and Odiel rivers discharge after running through a metalliferous mining area in the Iberian Pyrite Belt and end in common estuary called Ría of Huelva. Lead is a highly toxic and widely distributed element in the aquatic environment; therefore there is a great interest in assessing the impact of this contaminant on aquatic organisms. To study the bioavailability and sources of lead, the bivalve species Chamelea gallina was collected from six sampling sites along the coast of Huelva. Besides the effect of this metal on the enzyme activity, delta-aminolevulinic acid dehydratase (ALA-D) was determined in the whole tissue. Results show the inverse relationship between the lead concentration and the activity of ALA-D measured in whole tissues (r2=0.7). Individuals collected from the Ría of Huelva estuary had the highest levels of total lead concentrations and the lowest activity of ALA-D. Lead isotope analyses demonstrated the different sources of lead contamination and also confirmed the influence of Ría of Huelva on the metal input to the marine environment.
Judit Kalman; Inmaculada Riba; Julián Blasco; T Angel DelValls
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-26
Journal Detail:
Title:  Marine environmental research     Volume:  66     ISSN:  0141-1136     ISO Abbreviation:  Mar. Environ. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882895     Medline TA:  Mar Environ Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-40     Citation Subset:  IM    
Instituto de Ciencias Marinas de Andalucía, CSIC Polígono Río San Pedro s/n, Puerto Real Cádiz, Spain.
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MeSH Terms
Biological Markers / analysis
Bivalvia / enzymology*
Environmental Exposure / analysis*
Environmental Monitoring / methods*
Lead / administration & dosage*,  analysis,  pharmacology*
Oceans and Seas
Porphobilinogen Synthase / metabolism*
Reg. No./Substance:
0/Biological Markers; 7439-92-1/Lead; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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