Document Detail


delta 9-Tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex.
MedLine Citation:
PMID:  6329417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 3 cannabinoids, delta 9-tetrahydrocannabinol (delta 9-THC), 11-OH-delta 9-tetrahydrocannabinol (11-OH-delta 9-THC) and cannabidiol (CBD) on the binding of [3H]dihydroalprenolol [( 3H]DHA) to mouse brain beta-adrenergic receptors were determined. In vitro, delta 9-THC and 11-OH-delta 9-THC increased the specific binding of [3H]DHA. The increased specific binding of [3H]DHA was due to an increase in receptor affinity as indicated by a decrease in the dissociation constant (Kd). CBD had no effect on binding. Chronic administration of delta 9-THC in vivo caused a decrease in the number of [3H]DHA binding sites with no change in Kd.
Authors:
C J Hillard; A S Bloom
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  235     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1984-08-13     Completed Date:  1984-08-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  370-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cannabidiol / pharmacology
Cerebral Cortex / drug effects,  metabolism*
Dihydroalprenolol / metabolism
Male
Mice
Mice, Inbred ICR
Receptors, Adrenergic, beta / drug effects,  metabolism*
Tetrahydrocannabinol / pharmacology*
Grant Support
ID/Acronym/Agency:
DA 00124/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 13956-29-1/Cannabidiol; 1972-08-3/Tetrahydrocannabinol; 60106-89-0/Dihydroalprenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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