Document Detail

The delivery of protein into living cells by use of membrane fusible erythrocyte ghosts.
MedLine Citation:
PMID:  11163993     Owner:  NLM     Status:  MEDLINE    
We examined the effects of pretreatment of monkey kidney normal cells (CV-1) and human cervical tumor cells (HeLa) with membrane fusible erythrocyte ghosts (MFEG) encapsulating superoxide dismutase (SOD-MFEG) on adriamycin (ADM) cytotoxicity. The decrease in CV-1 cells with ADM was inhibited markedly, and the initiation of decrease in HeLa cells was delayed for 2 days by the pretreatment with SOD-MFEG, indicating that the delivered SOD held the activity in the cells.
K Kogure; T Itoh; O Okuda; K Hayashi; M Ueno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  210     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-15     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage
Cell Line
Doxorubicin / administration & dosage
Drug Delivery Systems*
Erythrocyte Membrane / metabolism*
Fluorescent Dyes
Hela Cells
Microscopy, Fluorescence
Proteins / administration & dosage*
Superoxide Dismutase / administration & dosage
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Fluorescent Dyes; 0/Proteins; 23214-92-8/Doxorubicin; 3326-32-7/Fluorescein-5-isothiocyanate; EC Dismutase

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