Document Detail


The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels.
MedLine Citation:
PMID:  15885459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although it is generally believed that paracetamol can be used as a marker of gastric emptying, there have been reports in the literature that show delayed dissolution of immediate release paracetamol tablets using standard in vitro setups and food-simulating media, delayed disintegration of paracetamol products in the fed stomach, and no correlation of paracetamol absorption with gastric emptying in the fed state. In this study, we confirmed that dissolution of Panodil and Apotel tablets is delayed in food-simulating media regardless of the in vitro hydrodynamics and on a formulation dependent manner. Further, we assessed the usefulness of in vitro dissolution data in the prediction of delayed disintegration time in the fed stomach and we examined the importance of delayed gastric disintegration on the onset of plasma levels using the canine model. In vitro dissolution data in cow's milk reflected the delayed disintegration of Panodil tablets in the fed stomach. In vitro dissolution of Apotel tablets in milk was delayed less than of Panodil and the effect of dosing conditions on the in vivo disintegration was not apparent. However, for the products tested in this study, there was no correlation between intragastric disintegration and onset of plasma levels probably because gastric emptying in also delayed in the fed state.
Authors:
Lida Kalantzi; Britta Polentarutti; Tamsin Albery; Dimitris Laitmer; Bertil Abrahamsson; Jennifer Dressman; Christos Reppas
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-04-07
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  296     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Affiliation:
Laboratory of Biopharmaceutics and Pharmacokinetics, National & Kapodistrian University of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / administration & dosage,  blood*
Animals
Dogs
Fasting / metabolism
Food-Drug Interactions / physiology*
Gastric Emptying / drug effects,  physiology*
Gastrointestinal Contents* / drug effects
Male
Milk / metabolism*
Predictive Value of Tests
Solubility
Time Factors
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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