Document Detail

The degree of ST-segment depression on symptom-limited exercise testing: relation to the myocardial ischemic burden as determined by thallium-201 scintigraphy.
MedLine Citation:
PMID:  7832128     Owner:  NLM     Status:  MEDLINE    
This study sought to determine the relation between the magnitude of exercise-induced ST depression and the ischemic burden as determined by quantitative thallium-201 scintigraphy. One hundred forty-four consecutive patients were prospectively studied with symptom-limited exercise testing and thallium-201 scintigraphy. Of these patients, 37 had between 1.0 and < 2.0 mm (group 1) and 17 had > or = 2.0 mm (group 2) of exercise-induced ST depression. There were no significant differences between groups 1 and 2 with respect to all exercise parameters including peak exercise heart rate (134 +/- 21 vs 144 +/- 26 beats/min), metabolic equivalents achieved (7.9 +/- 3.0 vs 8.6 +/- 3.3), and exercise time (7.4 +/- 2.7 minutes in both groups). There was no significant difference in the prevalence of thallium-201 redistribution defects in group 1 versus group 2 patients (17 of 37 [46%] vs 8 of 17 [47%]), and in the extent of ischemia as determined by the number of redistribution defects per patient (1.2 +/- 1.8 vs 1.2 +/- 1.5, respectively). Thus, in this consecutive group of patients with exercise-induced ST depression, those with > or = 2.0 mm of ST depression, relative to patients with a lesser degree of ST depression, had comparable exercise capacity and comparable ischemic burden by thallium-201 scintigraphic assessment. We conclude that the magnitude of ST depression on symptom-limited exercise testing does not correlate with the extent of ischemia as assessed by quantitative thallium-201 scintigraphy.
A J Taylor; M C Sackett; G A Beller
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  75     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-02-21     Completed Date:  1995-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  AIM; IM    
Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville 22908.
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MeSH Terms
Exercise Test
False Positive Reactions
Middle Aged
Myocardial Ischemia / physiopathology*,  radionuclide imaging*
Prospective Studies
Thallium Radioisotopes / diagnostic use
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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