| The degradative resistance of polyhedral oligomeric silsesquioxane nanocore integrated polyurethanes: an in vitro study. | |
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MedLine Citation:
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PMID: 16253324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymer biostability is one of the critical parameters by which these materials are selected for use as biomedical devices. This is the major rationale for the use of polymers which are highly crystalline and stiff namely expanded polytetrafluoroethylene (ePTFE) and Dacron in particular, as arterial bypass grafts. While this is immaterial in high-flow states, it becomes critically important at lower flows with a greater need for more compliant vessels. Polyurethanes being one of the most compliant polymers known are as such, the natural choice to build such constructs. However, concerns regarding their resistance to degradation have limited their use as vascular prostheses and in order to augment their strength, herein a novel polyhedral oligomeric silsesquioxane integrated poly(carbonate-urea)urethane (POSS-PCU) nanocomposite was synthesised by our group. In the following series of experiments, the POSS-PCU nanocomposite samples were exposed to accelerated degradative solutions, in an 'in-house' established model in vitro for up to 70 days before being subjected to infra-red spectroscopy, scanning electron microscopy, stress-strain studies and differential scanning calorimetry. Our results demonstrate that these silsesquioxane nanocores shield the soft segment(s) of the polyurethane, responsible for its compliance and elasticity from all forms of degradation, principally oxidation and hydrolysis. These nanocomposites hence provide an optimal method by which these polymers may be strengthened whilst maintaining their elasticity, making them ideal as vascular prostheses particularly at low flow states. |
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Authors:
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Ruben Y Kannan; Henryk J Salacinski; Marianne Odlyha; Peter E Butler; Alexander M Seifalian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-25 |
Journal Detail:
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Title: Biomaterials Volume: 27 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 1971-9 Citation Subset: IM |
Affiliation:
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Biomaterials & Tissue Engineering Centre (BTEC), Academic Division of Surgical and Interventional Sciences, University College London, Rowland Hill, Hampstead, London NW3 2PF, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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chemistry* Biodegradation, Environmental Blood Vessel Prosthesis* Elasticity Materials Testing Nanostructures / chemistry Polymers / chemistry* Polyurethanes / chemistry* Siloxanes / chemistry* Spectroscopy, Fourier Transform Infrared Stress, Mechanical Surface Properties Temperature |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polymers; 0/Polyurethanes; 0/Siloxanes; 0/poly(carbonate urea) urethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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