Document Detail


A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction.
MedLine Citation:
PMID:  22939314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite remarkable effectiveness of reperfusion and drug therapies to reduce morbidity and mortality following myocardial infarction (MI), many patients have debilitating symptoms and impaired left ventricular (LV) function highlighting the need for improved post-MI therapies. A promising concept currently under investigation is intramyocardial injection of high-water content, polymeric biomaterial gels (e.g., hydrogels) to modulate myocardial scar formation and LV adverse remodeling. We propose a degradable, bioactive hydrogel that forms a unique microstructure of continuous, parallel capillary-like channels (Capgel). We hypothesize that the innovative architecture and composition of Capgel can serve as a platform for endogenous cell recruitment and drug/cell delivery, therefore facilitating myocardial repair after MI.
Authors:
Domenico G Della Rocca; Bradley J Willenberg; Leonardo F Ferreira; Prateek S Wate; John W Petersen; Eileen M Handberg; Tong Zheng; Dennis A Steindler; Naohiro Terada; Christopher D Batich; Barry J Byrne; Carl J Pepine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-28
Journal Detail:
Title:  Medical hypotheses     Volume:  79     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-03-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  673-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
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MeSH Terms
Descriptor/Qualifier:
Alginates / chemistry*
Humans
Hydrogels
Microscopy, Electron, Scanning
Myocardial Infarction / therapy*
Stem Cell Factor / administration & dosage*
Stem Cell Transplantation*
Grant Support
ID/Acronym/Agency:
2UM1 HL087366-06/HL/NHLBI NIH HHS; K99 HL098453/HL/NHLBI NIH HHS; NS055165/NS/NINDS NIH HHS; R00 HL098453/HL/NHLBI NIH HHS; U01 HL087366/HL/NHLBI NIH HHS; UL1 TR000064/TR/NCATS NIH HHS; UL1 TR000064/TR/NCATS NIH HHS; UM1 HL087366/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Alginates; 0/Hydrogels; 0/Stem Cell Factor
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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