| A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction. | |
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MedLine Citation:
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PMID: 22939314 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite remarkable effectiveness of reperfusion and drug therapies to reduce morbidity and mortality following myocardial infarction (MI), many patients have debilitating symptoms and impaired left ventricular (LV) function highlighting the need for improved post-MI therapies. A promising concept currently under investigation is intramyocardial injection of high-water content, polymeric biomaterial gels (e.g., hydrogels) to modulate myocardial scar formation and LV adverse remodeling. We propose a degradable, bioactive hydrogel that forms a unique microstructure of continuous, parallel capillary-like channels (Capgel). We hypothesize that the innovative architecture and composition of Capgel can serve as a platform for endogenous cell recruitment and drug/cell delivery, therefore facilitating myocardial repair after MI. |
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Authors:
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Domenico G Della Rocca; Bradley J Willenberg; Leonardo F Ferreira; Prateek S Wate; John W Petersen; Eileen M Handberg; Tong Zheng; Dennis A Steindler; Naohiro Terada; Christopher D Batich; Barry J Byrne; Carl J Pepine |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-28 |
Journal Detail:
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Title: Medical hypotheses Volume: - ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA; Division of Cardiology, University of Rome ''Tor Vergata'', Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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