Document Detail

A deformation-based morphometry study of patients with early-stage Parkinson's disease.
MedLine Citation:
PMID:  19912319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Previous volumetric magnetic resonance imaging (MRI) studies of Parkinson's disease (PD) utilized primarily voxel-based morphometry (VBM), and investigated mostly patients with moderate- to late-stage disease. We now use deformation-based morphometry (DBM), a method purported to be more sensitive than VBM, to test for atrophy in patients with early-stage PD. METHODS: T1-weighted MRI images from 24 early-stage PD patients and 26 age-matched normal control subjects were compared using DBM. Two separate studies were conducted, where two minimally-biased nonlinear intensity-average were created; one for all subjects and another for just the PD patients. The DBM technique creates an average population-based MRI-average in an iterative hierarchical fashion. The nonlinear transformations estimated to match each subject to the MRI-average were then analysed. RESULTS: The DBM comparison between patients and controls revealed significant contraction in the left cerebellum, and non-significant trends towards frontal, temporal and cingulate sulcal expansions with frontal and temporal white matter contractions. Within the patient group, the unified PD rating scores were highly correlated with local expansions in or near sulci bordering on frontal and temporal cortex. CONCLUSION: Our results suggest that DBM could be a sensitive method for detecting morphological changes in early-stage PD.
P Borghammer; K Østergaard; P Cumming; A Gjedde; A Rodell; N Hall; M M Chakravarty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-11
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  17     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-20     Citation Subset:  IM    
PET Centre, Aarhus University Hospitals, Aarhus, Denmark.
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MeSH Terms
Brain / pathology*
Case-Control Studies
Disease Progression
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Middle Aged
Neuropsychological Tests
Nonlinear Dynamics
Parkinson Disease / diagnosis,  drug therapy,  pathology*
Regression Analysis
Sensitivity and Specificity
Severity of Illness Index
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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