| A defined human gastrin sequence stimulates the growth of Helicobacter pylori. | |
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MedLine Citation:
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PMID: 12480109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes the interaction between gastrin and Helicobacter pylori. Human gastrin amino acids 4-17 were found to be the minimal growth-stimulating sequence. Gastrin from other mammals did not stimulate bacterial growth. When human serum was used to stimulate bacterial growth in brucella broth, gastrin was shown to be a necessary and sufficient growth-stimulating factor. Competition for the gastrin effect by pentagastrin and cholecystokinin (CCK-8) resulted in inhibition of bacterial growth. This effect was mediated by the four C-terminal amino acids which are shared by gastrin, CCK-8 and pentagastrin. In conclusion, the interaction between gastrin and H. pylori was shown to be specific, essential, and dependent on a defined gastrin sequence. |
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Authors:
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Michal Yael Chowers; Nathan Keller; Simon Bar-Meir; Yehuda Chowers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS microbiology letters Volume: 217 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-13 Completed Date: 2003-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Federation of European Microbiological Societies |
Affiliation:
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Infectious Disease Unit, Meir Hospital, Sapir Medical Center, Kfar Saba 44281, Israel. chowersm@post.tau.ac.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Amino Acids / classification, metabolism Gastrins / chemistry*, pharmacology* Helicobacter pylori / drug effects*, genetics, growth & development* Humans Molecular Sequence Data Pentagastrin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Gastrins; 0/gastrin (4-17); 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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