Document Detail


A deficient maternal calcium intake during pregnancy increases blood pressure of the offspring in adult rats.
MedLine Citation:
PMID:  12066944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess in an animal model the effect of maternal dietary calcium intake during pregnancy on the blood pressure of offspring. DESIGN: Randomised controlled trial. SAMPLE: Ninety-eight 20-week-old female Wistar-Kyoto rats, giving birth to a total of 119 pups that were included in the follow up study. METHODS: Rats were randomised to a calcium deficient diet, a diet with the recommended calcium levels, or a diet with calcium content much higher than the recommended levels. After one month on the experimental diet they were bred. After birth, systolic blood pressure in the offspring was measured monthly till 52 weeks of age. MAIN OUTCOME MEASURES: Blood pressure of the offspring. RESULTS: The difference in blood pressure of the offspring between the normal and low maternal calcium group increased 0.49 mmHg per month (95% CI 0.18 to 0.84), 0.38 (0.07 to 0.68) between the low and high calcium group, and 0.12 (-0.20 to 0.43) between the normal and high calcium group. At the end of the follow up (52 weeks of age) blood pressure of the offspring in the deficient calcium group was 12.1 mmHg (95% CI 8.8 to 15.4, P < 0.0001) higher than in the normal calcium group and 7.5 mmHg (95% CI 4.4 to 10.5, P < 0.001) higher than the high calcium group. Blood pressure of the offspring in the high calcium group was 4.3 mmHg (95% CI 1.0 to 7.5, P = 0.01) higher than in the normal calcium group. In a multiple regression model maternal calcium intake during pregnancy was the strongest predictor of blood pressure of the offspring during adulthood. CONCLUSIONS: This experiment supports previous studies in humans suggesting a link between calcium intake during pregnancy and blood pressure in the offspring, and provides an animal model to explore the mechanisms involved in such association.
Authors:
Eduardo Bergel; José M Belizán
Related Documents :
16649734 - Sodium and potassium excretion in normotensive and hypertensive population in kashmir.
21723554 - Casein hydrolysate containing val-pro-pro and ile-pro-pro improves central blood pressu...
10855734 - Blood pressure changes in relation to sodium and calcium status in induced hyperinsulin...
6846214 - Low blood pressure in vegetarians: the possible role of potassium.
17785274 - Assessing the impacts of agricultural intensification on biodiversity: a british perspe...
3318374 - Changes in vascular endothelium and its function in systemic arterial hypertension.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  109     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-17     Completed Date:  2002-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  540-5     Citation Subset:  AIM; IM    
Affiliation:
Latin American Centre for Perinatology, Pan American Health Organization, World Health Organization, Montevideo, Uruguay.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Calcium / deficiency*
Calcium, Dietary / administration & dosage*
Female
Gestational Age
Hypertension / embryology*
Models, Animal
Pregnancy
Rats
Rats, Inbred WKY
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine in...
Next Document:  Altered vascular function in healthy normotensive pregnant women with bilateral uterine artery notch...