Document Detail

A defect in the cell cycle of neuroglia in the myelin deficient jimpy mouse.
MedLine Citation:
PMID:  3676844     Owner:  NLM     Status:  MEDLINE    
One h after receiving a single pulse of [3H]thymidine, spinal cords from jimpy and control animals were examined for labeled cells and for cells in mitosis. Although the number of labeled cells was significantly higher in jimpy spinal cords at 14 and 20 days postnatal, the number of mitotic cells was not. In normal animals, the ratio of the number of labeled cells to the number of mitotic cells (L:M) was close to 4:1 regardless of the age of the animal or the labeling index. In jimpy animals, the L:M ratio was always close to 8:1. Previous ultrastructural studies have shown that the great majority of [3H]thymidine-labeled cells in jimpy central nervous system (CNS) at these ages are oligodendrocytes. Therefore, the unusually high L:M ratio indicates that there is an abnormality in some aspect of the jimpy oligodendroglial cell cycle.
P E Knapp; R P Skoff
Related Documents :
6502604 - Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidin...
20405184 - Proliferation of rat molar pulp cells after direct pulp capping with dentine adhesive a...
9025914 - Quantification of cell-matrix and cell-cell adhesion using horseradish peroxidase.
7806474 - Ongoing proliferation of melanocytes in the stria vascularis of adult guinea pigs.
9150394 - Role of p21waf1/cip1/sdi1 in cell death and dna repair as studied using a tetracycline-...
10628814 - Cell-dependent mechanisms restrict the hiv type 1 coreceptor activity of us28, a chemok...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  432     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-20     Completed Date:  1988-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Count
Cell Cycle*
Mice, Jimpy / physiology*
Mice, Neurologic Mutants / physiology*
Myelin Sheath / physiology
Neuroglia / cytology*
Thymidine / diagnostic use
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Growth of corticospinal axons on prosthetic substrates introduced into the spinal cord of neonatal r...
Next Document:  One-trial olfactory learning enhances olfactory bulb responses to an appetitive conditioned odor in ...