Document Detail


A defect in the cell cycle of neuroglia in the myelin deficient jimpy mouse.
MedLine Citation:
PMID:  3676844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One h after receiving a single pulse of [3H]thymidine, spinal cords from jimpy and control animals were examined for labeled cells and for cells in mitosis. Although the number of labeled cells was significantly higher in jimpy spinal cords at 14 and 20 days postnatal, the number of mitotic cells was not. In normal animals, the ratio of the number of labeled cells to the number of mitotic cells (L:M) was close to 4:1 regardless of the age of the animal or the labeling index. In jimpy animals, the L:M ratio was always close to 8:1. Previous ultrastructural studies have shown that the great majority of [3H]thymidine-labeled cells in jimpy central nervous system (CNS) at these ages are oligodendrocytes. Therefore, the unusually high L:M ratio indicates that there is an abnormality in some aspect of the jimpy oligodendroglial cell cycle.
Authors:
P E Knapp; R P Skoff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  432     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-20     Completed Date:  1988-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Cell Count
Cell Cycle*
Male
Mice
Mice, Jimpy / physiology*
Mice, Neurologic Mutants / physiology*
Mitosis
Myelin Sheath / physiology
Neuroglia / cytology*
Thymidine / diagnostic use
Grant Support
ID/Acronym/Agency:
NS 15338/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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