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The decrease in prolidase activity in myeloproliferative neoplasms.
MedLine Citation:
PMID:  23457135     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The development of bone marrow fibrosis is a severe complication in hematological diseases. The progress of bone marrow myelofibrosis is evaluated by a trephine examination and may be characterized by the biochemical markers of collagen turnover determination.
OBJECTIVES: Investigation of serum prolidase activity and biochemical markers of collagen metabolism in order to establish its role in the development of bone marrow fibrosis.
MATERIAL AND METHODS: The group of 37 patients with myeloproliferative neoplasms (MPN) before treatment, consisted of 16 patients with chronic myeloid leukemia (CML), 7 with primary myelofibrosis (PMF), 8 with essential thrombocythopenia (ET), and 6 with polycythemia vera (PV).
RESULTS: It was found that the plasma activity of prolidase (Pro) was reduced to almost half together with the serum level of osteocalcin (BGL), and hydroxyproline (H-PRO) in the serum and urine of patients with MPN in comparison to the control group. In the MPN group of patients, the levels of N-terminal procollagen III peptide (PIIINP), type I procollagen (PICP) and the C-terminal telopeptide of type I collagen (ICTP) were significantly higher.
CONCLUSIONS: The alteration of collagen turnover markers in the MPN patient group (the elevation of synthesis and inhibition of collagen catabolism rate) has suggested that a diminished prolidase activity may contribute to such alteration of collagen metabolism and should be consider a biomarker of MPN progress.
Authors:
Jadwiga Nowicka; Wiesława Nahaczewska; Henryk Owczarek; Mieczysław Woźniak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in clinical and experimental medicine : official organ Wroclaw Medical University     Volume:  21     ISSN:  1899-5276     ISO Abbreviation:  Adv Clin Exp Med     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2013-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101138582     Medline TA:  Adv Clin Exp Med     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  767-71     Citation Subset:  IM    
Affiliation:
Department of Medical Laboratory Diagnostics, Wroclaw Medical University, Poland.
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