Document Detail

A decrease in clonus amplitude by topical anesthesia.
MedLine Citation:
PMID:  2415326     Owner:  NLM     Status:  MEDLINE    
Skin desensitization by topical anesthetic was studied for its effects on the frequency and amplitude of 3 overt involuntary oscillations of the ankle: pathological clonus, physiological clonus, and physiological action tremor. Pathological clonus was studied in two spinal cord patients, physiological clonus in 3 normal subjects following prolonged exercise, and physiological action tremor in 7 normal subjects performing voluntary movements. Topical anesthetic applied to the skin of the leg, ankle and proximal half of the foot resulted in a significant decrease in the amplitude of all 3 oscillations with no significant change in frequency. The effect of topical anesthetic on pathological clonus amplitude was so profound that neither patient could initiate clonus for approximately 30 min, despite repeated attempts to do so. While the mechanism determining the frequencies of these oscillations is a matter of considerable debate, the consistency in their response to topical anesthetic suggests that a common mechanism may exist. A possible clinical application is suggested. Topical anesthetic may be a non-invasive means of attenuating undesirable large amplitude tremors and clonus.
W J Mills; R S Pozos
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Electroencephalography and clinical neurophysiology     Volume:  61     ISSN:  0013-4694     ISO Abbreviation:  Electroencephalogr Clin Neurophysiol     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-10     Completed Date:  1986-01-10     Revised Date:  2008-09-09    
Medline Journal Info:
Nlm Unique ID:  0375035     Medline TA:  Electroencephalogr Clin Neurophysiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  509-18     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Anesthetics / administration & dosage
Ankle / physiology*
Movement* / drug effects
Myoclonus / physiopathology
Spinal Cord / physiology
Reg. No./Substance:

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