| The declining phase of lactation: peripheral or central, programmed or pathological? | |
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MedLine Citation:
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PMID: 17286209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In most species the functional activity of the mammary gland during lactation follows a biphasic developmental pattern. This pattern starts with a rapid increase in milk output that occurs with secretory activation and continues with a more gradual increase until the point of peak lactation is reached. Following this gain-of-function phase, the ability of the gland to produce milk decreases. This decrease occurs even if the lactation is prolonged by the presence of continued suckling stimulus and complete milk removal. This review describes the current state of our knowledge concerning the factors that regulate milk synthesis capacity by the mammary gland during the lactation cycle. The review describes four potential alternatives as mechanisms governing the process, which we refer to as secretory diminution. These alternatives are not presented as mutually exclusive of each other or other possible mechanisms, but are proposed as potential contributing mechanisms. |
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Authors:
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Darryl Hadsell; Jessy George; Daniel Torres |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Journal of mammary gland biology and neoplasia Volume: 12 ISSN: 1083-3021 ISO Abbreviation: J Mammary Gland Biol Neoplasia Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-04-13 Completed Date: 2007-11-08 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9601804 Medline TA: J Mammary Gland Biol Neoplasia Country: United States |
Other Details:
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Languages: eng Pagination: 59-70 Citation Subset: IM |
Affiliation:
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USDA Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030, USA. dhadsell@bcm.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Female Humans Lactation / physiology* Mammary Glands, Animal / physiology* Mammary Glands, Human / physiology* Mice |
| Grant Support | |
ID/Acronym/Agency:
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DK52197/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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