| A decline in walking distance predicts long-term outcome in patients with known or suspected peripheral artery disease. | |
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MedLine Citation:
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PMID: 19838118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the predictive value of a decline in total walking distance and ankle brachial index (ABI) on all-cause mortality and cardiac death in patients with known or suspected peripheral artery disease. METHODS: Two hundred and sixty-one patients, who performed single-stage treadmill walking test twice to evaluate their peripheral artery disease, were enrolled in an observational study. Patients who underwent surgery during follow-up were excluded. Delta total walking distance and delta resting and exercise ABI consisted of the difference between the first and the second test. All three variables were categorized into two groups: stable/improvement or a decline. RESULTS: The mean follow-up period was 6 years. At both 5 years and total follow-up, a decline in total walking distance was independent and highly associated with an increased mortality risk and cardiac death [hazard ratio: 2.31 (95% confidence interval 1.35-3.96); hazard ratio: 3.55 (95% confidence interval: 1.53-8.21), respectively]. A decline in resting or exercise ABI after adjustment for delta walking distance was not significantly associated with all-cause mortality or cardiac death. CONCLUSION: A decline in total walking distance in single-stage treadmill exercise tests is a strong prognostic predictor of all-cause mortality and cardiac death in the short term and long term. |
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Authors:
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Inge I de Liefde; Ron T van Domburg; Jeroen J Bax; Jan Klein; Hence J M Verhagen; Don Poldermans |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 17 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 321-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle Brachial Index Chi-Square Distribution Exercise Test* Exercise Tolerance* Female Heart Diseases / etiology, mortality Humans Kaplan-Meiers Estimate Linear Models Male Middle Aged Netherlands / epidemiology Peripheral Vascular Diseases / complications, diagnosis*, mortality, physiopathology Predictive Value of Tests Prognosis Proportional Hazards Models Risk Assessment Risk Factors Time Factors Walking* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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