| Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance. | |
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MedLine Citation:
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PMID: 19269138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Individuals with schizophrenia show deficits in cognitive functioning, as evidenced by deficits on neurocognitive tasks such as the Wisconsin Card Sorting Task (WCST). Studies of risk/reward decision-making in individuals with schizophrenia have yielded mixed results, and few studies have examined systematically the relationship between these domains and their relationship with clinical factors. METHOD: Thirty-two smokers with schizophrenia, ten non-smokers with schizophrenia, nine non-psychiatric non-smokers and ten non-psychiatric smokers were administered computerized versions of the Iowa Gambling Task (IGT) and the WCST. Smokers were allowed to smoke adlibitum during designated breaks in order to prevent deprivation. RESULTS: Subjects with schizophrenia performed significantly worse than non-psychiatric controls on both the IGT and the WCST, and performance on these tasks was significantly correlated across subject groups. Among women with schizophrenia, smokers performed significantly better than non-smokers on the IGT. CONCLUSIONS: Individuals with schizophrenia perform worse than controls on the IGT, suggesting impairments in risk/reward decision-making. Correlations between IGT and WCST performance suggest a shared element underlying task performance, such as a deficit in set-shifting or perseverance. Further research is needed to establish the relationship between cigarette smoking and IGT performance in schizophrenia. |
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Authors:
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Sarah W Yip; Kristi A Sacco; Tony P George; Marc N Potenza |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-03-09 |
Journal Detail:
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Title: Schizophrenia research Volume: 110 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-07-07 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 156-64 Citation Subset: IM |
Affiliation:
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Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 2 Church Street South, Suite 215, New Haven, CT, United States. sarah.yip@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cognition Disorders / drug therapy, etiology* Decision Making / drug effects, physiology* Female Gambling Humans Impulse Control Disorders / etiology Male Middle Aged Neuropsychological Tests Psychiatric Status Rating Scales Reward* Risk Schizophrenia / complications* Schizophrenic Psychology* Sex Factors Smoking / physiopathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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5-R01 DA-013672/DA/NIDA NIH HHS; 5K02-DA-016611/DA/NIDA NIH HHS; 5R01-DA-014039/DA/NIDA NIH HHS; K02 DA016611-03/DA/NIDA NIH HHS; R01 DA013672-04/DA/NIDA NIH HHS; R01 DA014039-03/DA/NIDA NIH HHS; R01 DA019039/DA/NIDA NIH HHS; R01 DA019039-03/DA/NIDA NIH HHS; RL1 AA017539/AA/NIAAA NIH HHS; RL1 AA017539-01/AA/NIAAA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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