Document Detail


Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance.
MedLine Citation:
PMID:  19269138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Individuals with schizophrenia show deficits in cognitive functioning, as evidenced by deficits on neurocognitive tasks such as the Wisconsin Card Sorting Task (WCST). Studies of risk/reward decision-making in individuals with schizophrenia have yielded mixed results, and few studies have examined systematically the relationship between these domains and their relationship with clinical factors.
METHOD: Thirty-two smokers with schizophrenia, ten non-smokers with schizophrenia, nine non-psychiatric non-smokers and ten non-psychiatric smokers were administered computerized versions of the Iowa Gambling Task (IGT) and the WCST. Smokers were allowed to smoke adlibitum during designated breaks in order to prevent deprivation.
RESULTS: Subjects with schizophrenia performed significantly worse than non-psychiatric controls on both the IGT and the WCST, and performance on these tasks was significantly correlated across subject groups. Among women with schizophrenia, smokers performed significantly better than non-smokers on the IGT.
CONCLUSIONS: Individuals with schizophrenia perform worse than controls on the IGT, suggesting impairments in risk/reward decision-making. Correlations between IGT and WCST performance suggest a shared element underlying task performance, such as a deficit in set-shifting or perseverance. Further research is needed to establish the relationship between cigarette smoking and IGT performance in schizophrenia.
Authors:
Sarah W Yip; Kristi A Sacco; Tony P George; Marc N Potenza
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-03-09
Journal Detail:
Title:  Schizophrenia research     Volume:  110     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-07-07     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cognition Disorders / drug therapy,  etiology*
Decision Making / drug effects,  physiology*
Female
Gambling
Humans
Impulse Control Disorders / etiology
Male
Middle Aged
Neuropsychological Tests
Psychiatric Status Rating Scales
Reward*
Risk
Schizophrenia / complications*
Schizophrenic Psychology*
Sex Factors
Smoking / physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
5-R01 DA-013672/DA/NIDA NIH HHS; 5K02-DA-016611/DA/NIDA NIH HHS; 5R01-DA-014039/DA/NIDA NIH HHS; K02 DA016611-03/DA/NIDA NIH HHS; R01 DA013672-04/DA/NIDA NIH HHS; R01 DA014039-03/DA/NIDA NIH HHS; R01 DA019039/DA/NIDA NIH HHS; R01 DA019039/DA/NIDA NIH HHS; R01 DA019039-03/DA/NIDA NIH HHS; RL1 AA017539/AA/NIAAA NIH HHS; RL1 AA017539/AA/NIAAA NIH HHS; RL1 AA017539-01/AA/NIAAA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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