| The decay of blood lead levels in workers suspended under the control of lead at work regulations. | |
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MedLine Citation:
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PMID: 15799994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To study the rate of decline in blood lead levels post-suspension under Control of Lead at Work Regulations (CLAW) and thereby suggest sampling frequencies for follow-up blood lead measurements. METHODS: A retrospective cohort of lead workers with blood lead levels over the current suspension level were identified from blood lead records. Data on their suspension and follow-up blood lead measurements were obtained. RESULTS: Sixteen per cent of the identified cohort did not appear to return to lead work under CLAW. Twenty-seven suspension cases with an initial mean blood lead of 79 microg/dl (3.82 micromol/l) formed the dataset for analysis of decline in blood lead levels. The mean length of time between the blood sample indicating suspension and the first follow-up blood sample was 32 days. The mean length of suspension under CLAW was 61 days. The mean initial rate of blood lead decay was 0.659 microg/dl per day (0.032 micromol/l per day), although with a wide range. The rate of decline in blood lead after suspension was increased by the blood lead level at suspension, but was decreased by increasing past cumulative exposure. CONCLUSIONS: A follow-up blood lead sample 1 month after suspension should show a mean decrease between 13 and 26 microg/dl (0.63-1.25 micromol/l), which is substantially greater than that due to analytical 'noise' associated with two sequential measurements (approximately 5 microg/dl). Therefore, a follow-up blood sample taken around 3-4 weeks after suspension would seem practical. A decrease in blood lead of 7-8 mug/dl (0.36 micromol/l) or less in the month after suspension may suggest continuing lead exposure. |
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Authors:
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H Mason; N Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-03-30 |
Journal Detail:
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Title: Occupational medicine (Oxford, England) Volume: 55 ISSN: 0962-7480 ISO Abbreviation: Occup Med (Lond) Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-25 Completed Date: 2006-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205857 Medline TA: Occup Med (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 371-4 Citation Subset: IM |
Affiliation:
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Broad Lane--Health and Safety Laboratory, Sheffield, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemical Industry* Cohort Studies Humans Lead / blood*, toxicity Male Mass Screening Occupational Exposure / analysis* Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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