| Histone/protein deacetylases and T cell immune responses. | |
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MedLine Citation:
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PMID: 22246031 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clinical and experimental studies show that inhibition of histone/protein deacetylases (HDAC) can have important anti-neoplastic effects through cytotoxic and pro-apoptotic mechanisms. There are also increasing data from non-oncologic settings that HDAC inhibitors (HDACi) can exhibit useful anti-inflammatory effects in vitro and in vivo, unrelated to cytotoxicity or apoptosis. These effects can be cell, tissue or context-dependent, and can involve modulation of specific inflammatory signaling pathways, as well as epigenetic mechanisms. We review recent advances in the understanding of how HDACi alter immune and inflammatory processes, with a particular focus on the effects of HDACi on T cell biology, including the activation and functions of conventional T cells and the unique T cell subset, comprised of Foxp3+ T-regulatory cells. While studies are still needed to tease out details of the various biological roles of individual HDAC isoforms and their corresponding selective inhibitors, the anti-inflammatory effects of HDACi are already promising and may lead to new therapeutic avenues in transplantation and autoimmune diseases. |
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Authors:
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Tatiana Akimova; Ulf H Beier; Yujie Liu; Liqing Wang; Wayne W Hancock |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States; |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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