| The dawn of the RNA World: toward functional complexity through ligation of random RNA oligomers. | |
| | |
MedLine Citation:
|
PMID: 19318464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered. |
| | |
Authors:
|
Carlos Briones; Michael Stich; Susanna C Manrubia |
Related Documents
:
|
1637874 - Structural consensus of rna templates replicated by q beta replicase. 4630804 - Transcription during the development of bacteriophage phi29: definition of "early" and ... 21368204 - Somatic hypermutation of human mitochondrial and nuclear dna by apobec3 cytidine deamin... 8233824 - Methylphosphate cap structure increases the stability of 7sk, b2 and u6 small rnas in x... 17222694 - Coupling of rotavirus genome replication and capsid assembly. 9872574 - Measurement of genetic variation within and between japanese quail lines using dna fing... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-24 |
Journal Detail:
|
Title: RNA (New York, N.Y.) Volume: 15 ISSN: 1469-9001 ISO Abbreviation: RNA Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-16 Completed Date: 2009-05-08 Revised Date: 2013-06-02 |
Medline Journal Info:
|
Nlm Unique ID: 9509184 Medline TA: RNA Country: United States |
Other Details:
|
Languages: eng Pagination: 743-9 Citation Subset: IM |
Affiliation:
|
Centro de Astrobiología (CSIC-INTA), 28850 Torrejón de Ardoz, Madrid, Spain. brioneslc@inta.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biogenesis Evolution, Molecular* Inverted Repeat Sequences Nucleic Acid Conformation RNA, Catalytic / chemistry, genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Catalytic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential functions of two editosome exoUases in Trypanosoma brucei.
Next Document: Community-based adaptive physical activity program for chronic stroke: feasibility, safety, and effi...