| The dark side of high-intensity renal replacement therapy of acute kidney injury in critically ill patients. | |
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MedLine Citation:
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PMID: 20383609 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The impact of intensity or dose of renal replacement therapy (RRT) on outcome of critically ill patients has been a matter of controversy. Most definitions of an adequate dose of acute RRT are based on urea removal, while ignoring other crucial aspects of RRT adequacy in acute kidney injury (AKI). Although some clinical trials have found an improvement in survival with higher doses of intermittent hemodialysis or continuous RRT, results have not been consistent across all studies. The largest trials suggest that there is no additional survival benefit with doses of 35-45 ml/kg/h (CRRT) or daily intermittent hemodialysis. On the other hand, high-intensity treatment may cause life-threatening complications and thereby counteract the benefits of higher small-solute clearance. One important area for future investigations is the need to characterize the potential harm of high-dose RRT for AKI in critically ill patients. |
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Authors:
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Helmut Schiffl |
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Publication Detail:
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Type: Journal Article Date: 2010-04-10 |
Journal Detail:
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Title: International urology and nephrology Volume: 42 ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 435-40 Citation Subset: IM |
Affiliation:
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KfH Nierenzentrum M?nchen-Laim, Department of Internal Medicine-Campus Innenstadt, University of Munich, Elsenheimerstr. 63, 80687, Munchen, Germany. hschiffl@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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